Barry Weiss is a hotshot broker — smart, tough, and arrogant. When Barry needs a new heart, he descends into a comically callous world of inept doctors and hard-bitten nurses. Shortly after receiving a transplant, he finds that everything feels radically wrong, including emotions of kindness and compassion. In an effort to find out why, he tracks down the widow of his heart donor and begins a journey of discovery into the real meaning of his new heart.