Clark's plays include Edgewise, Recall, and Puppy. Her work has been developed at Manhattan Theatre Club, the Studio at Cherry Lane Theatre, Page 73, Ensemble Studio Theatre, The Provincetown Playhouse, The New York International Fringe Festival, and Yale University. In addition, she writes for the AMC show Rubicon, and she co-created, wrote, and performed in the Internet sitcom, Inconvenient Molly.

Launched in 2003 and awarded each year to an early-career playwright who has not received wide public recognition or production opportunities in New York City, the P73 Playwriting Fellowship provides year-long development support to one early-career playwright annually. Past recipients of the P73 Playwriting Fellowship are Kirsten Greenidge, Quiara Alegría Hudes, Jason Grote, Krista Knight, Tommy Smith, and Heidi Schreck.