Parabolizing world events through the lens of personal exchanges, Superman & Serena concerns well-known psychiatrist Fredrick Mullen now finding his private and professional lives challenged as a result of an encounter with Salma, a Muslim woman struggling with mental health issues. As both doctor and patient reconnect with long-lost aspects of their past, the stage is set for tragedy to strike Fredrick just as a new perspective on the future is within his grasp.