Inspired by Vega's own experience as an immigrant in New York City, The Duchamp Syndrome, which also features Omen Sade, tells the story of Juan, a solitary immigrant in The Big Apple, who dreams of stand-up comedy stardom. Juan is so lonely that he starts making friends, literally. An unusual assortment of fellow travelers, human and not, help him practice his routines and prepare for his mother's visit from Mexico (provided she can get a visa). He's got to impress. But is he being honest with her, and himself, about the new life he's making? The Duchamp Syndrome is a provocative love letter to New York, with guest appearances from a large cast of repurposed objects.