As actors, Randy and Jason Sklar have guest starred in many TV shows, including an Emmy Award winning episode of HBO’s Curb Your Enthusiasm, the FX hit “It’s Always Sunny in Philadelphia, as well as Adult Swim’s Childrens’ Hospital. They starred as conjoined twins in a memorable episode of Grey’s Anatomy and as warring agents on HBO’s Entourage. Of the Entourage episode, Entertainment Weekly television critic Paul Katz wrote of their turn, “in the hands of comedic masters, The Sklar Brothers, they made it soar.” They’ve also appeared in such films as Touchstone’s, Wild Hogs, and Fox Atomic’s, The Comebacks.
As stand up comedians, they recorded their second half hour Comedy Central Presents in November 2009 and it premiered in March of 2010. The Onion A.V. Club named their latest comedy CD Hendersons And Daughters in their Top 10 Comedy albums of 2011.