Directed by Robert Falls, the production received 2007 Tony Award nominations for Best Revival of a Play and Best Leading Actor in a Play for star Liev Schreiber. In addition, Schreiber received the 2007 Drama League Distinguished Performance Award, as well as Drama Desk and Outer Critics Circle Award nominations for his work.

The cast also includes Stephanie March, Peter Hermann, Michael Laurence, Sebastian Stan, Christine Pedi, Barbara Rosenblat, Adam Sietz, Marc Thompson, Kit Williamson, and Cornell Womack. Talk Radio has a set by Mark Wendland, costumes by Laura Bauer, lighting by Christopher Akerlind, and sound by Richard Woodbury.

In his review for TheaterMania, David Finkle wrote: "In the highly entertaining revival of Eric Bogosian's Talk Radio, Liev Schreiber proves conclusively that, despite a severe case of self-loathing, a man can walk with indomitable swagger."