The show is a dark, modern twist on the myth of the Ancient Greek sirens who lured sailors to their deaths with their songs. Here the turbulent sea is the music industry, and the siren is Skylar Cole, a seductive indie-rock singer in New York City who performs at the Siren's Den, a popular music venue.
Skylar's biggest fan is Remy Morgan, a young, aspiring singer who finds that her songwriting is fueled by her time spent with Skylar. Although Remy and Skylar form an immediate bond, their attempts at connection are thwarted by Skylar's hungry fans known as Vultures, her possessive personal assistant, her suspicious boyfriend, and her own sordid past. Soon Remy finds herself drawn into a world of drugs, lust, and empty promises, where some idols don't deserve pedestals and some dreams come with dire consequences. Will Remy find success, or will she fall prey to Skylar's siren song forever?