Lou is the story of Lou Salome, one of the first female psychoanalysts and an accomplished poet, novelist, and early scholar of the psychology of female sexuality. Lou had deeply intimate relationships with Freud, Nietzsche, and Rilke, along with other great thinkers of the day. Her brilliance matched (if not surpassed) that of these great men, though her work is hardly known. Through Salome's search for identity and fight to claim her place in a world dominated by men, this question arises: How far have we truly come? An all-female cast comes together to reclaim her story, portraying the famous men in her life through her own mind and memory.