Lost Again is a road dramedy about two mismatched strangers paired up by a mutual friend: Ilona Young, a type-A, know-it-all travel blogger on a cross-country assignment and Casey Calvino, a jaded comedian on a tour of the US. Their story is one of identity, pain, adventure, friendship, moving on and moving forward. Each act will take place in a city, or town, en-route from New York to Los Angeles. The story is part misadventure, part self-discovery, and part buddy dramedy.