Catholic school was wrong about hell. It's not fire and brimstone or gnashing of teeth. Hell is Madison, Wisconsin. Mo hates everything about Wisconsin: the people, the quiet, the cold, the psychiatric hospital where she works. Everything, that is, until she meets Ed, the blunt and kindhearted patient with a dark and infamous past. Through bad jokes, imagining New York City with no humans in it, and writing letters to Frank Sinatra, the two form a bond that they share with no one else. Ranging in scope from Catholicism to serial murder, Ed and Mo is a dark comedy that examines finding the people you never knew you needed.