Me, My Mouth and I will make its world premiere at the Cherry Lane Theatre.
Spanger made her Broadway debut in the role in 2002.
British actress Ruth Wilson makes her Broadway debut at Manhattan Theatre Club.
Previously announced stars include Rachel Ticotin, Brad Calcaterra, and Michael Musto.
The Shakespeare-inspired musical will have its world premiere production next year.
Further casting for the musical has been announced.
The Broadway veterans will team up for a late-night 54 Below cabaret.
Carlos Celdran's solo play about the life of Imelda Marcos will debut off-Broadway this fall.
Simon Stephens' new play is directed by Trip Cullman.
Signature Theatre will premiere the new play by Katori Hall.