The cast of the production was led by Audra McDonald and Norm Lewis in the title roles, with David Alan Grier, Phillip Boykin, Nikki Renee Daniels, Joshua Henry, Christopher Innvar, Bryonha Marie Parham, and NaTasha Yvette Williams. The company also included Sumayya Ali, Allison Blackwell, Roosevelt Andre Credit, Trevon Davis, Joseph Dellger, Wilkie Ferguson III, Carmen Ruby Floyd, Gavin Gregory, Heather Hill, David Hughey, Andrea Jones-Sojola, Alicia Hall Moran, Cedric Neal, Phumzile Sojola, Nathaniel Stampley, Julius Thomas III, J.D. Webster, and Lisa Nicole Wilkerson.
Directed by Diane Paulus, the production featured an adaptation of George and Ira Gershwin and Dubose and Dorothy Heyward's original text by Suzan-Lori Parks and Deidre L. Murray. The creative team also included choreographer Ronald K. Brown, set designer Riccardo Hernandez, costume designer ESosa, lighting designer Christopher Akerlind and sound designer Acme Sound Partners.