Written by playwright John Pielmeier (Agnes of God), the movie is adapted from Flora Rheta Schreiber's best-selling book about a young woman suffering from a severe multiple personality disorder. It is directed by Joseph Sargent, a four-time Emmy Award winner. Sybil was previously turned into a popular 1976 NBC-TV film that starred Sally Field (who won an Emmy Award for her performance) and Joanne Woodward.
Blanchard earned a Tony Award nomination for her performance as Louise in the revival of Gypsy, and won an Emmy for her performance as the young Judy Garland in Life With Judy Garland: Me and My Shadows. Lange, a two-time Oscar winner for Tootsie and Blue Sky, has appeared on Broadway as Amanda Wingfield in The Glass Mengarie and as Blanche DuBois in the 1992 revival of A Streetcar Named Desire.