The show, which features a script by Reubens and Bill Steinkellner, is based on the character and original stage pieces created by Reubens, as well as the subsequent television series and movies in which he appeared. Along with Reubens, the company features John Moody (Mailman Mike), Drew Powell (Bear), John Paragon (Jambi), Jesse Garcia (Sergio), Phil LaMarr (Cowboy Curtis), Lynne Marie Stewart (Miss Yvonne), Lance Roberts (King of Cartoons) and Josh Meyers (Firefighter).

The show's creative team includes Jay Cotton (original music), Basil Twist (puppet design), David Korins (scenic design), Ann Closs-Farley (costume design), Jeff Croiter (lighting design), M.L. Dogg (sound design), and Jake Pinholster (projection design).