The selection replaces Sylvia, which was to star Cindy Williams, who bowed out to lead the upcoming national tour of Nunsense.
Remember Me looks at a middle-aged couple dealing with the prospects of past and future lovers after their children have left the next.
DeWitt is best known for her performance as Janet Wood on the hit ABC sitcom Three's Company. She has also been seen in the Canadian productions of Dinner With Friends and The Last Night of Ballyhoo and, most recently, Off-Broadway in Miss Abigail's Guide to Dating, Mating & Marriage.
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