Little Fish, which is suggested by the short stories of Deborah Eisenberg, focuses on Charlotte, a young writer of short stories, who confronts her past, present and future in post 9/11 Manhattan. She quits smoking and embarks on a modern day odyssey as she attempts to fill her nicotine-starved days with swimming. The show had its New York premiere at the Second Stage Theatre.

The show's cast also includes Dina Morishita, German Santiago, and Samantha Shelton. The musical director is David O, with music supervision by Brad Ellis and orchestrations by Tony Award winner Bruce Coughlin. The set and lighting design is by Adam Rigg and costume design is by Bethany Jane Bohatila.

LaChiusa's other musicals include Hello Again, First Lady Suite, Marie Christine, and The Wild Party.