Clayburgh's many stage credits include The Sudden & Accidental Re-Education of Horse Johnson, The Rothschilds, Pippin, Jumpers, Design for Living, A Naked Girl on the Appian Way, The Clean House, and Barefoot in the Park.
Clayburgh received Oscar nominations for An Unmarried Woman and Starting Over. Her many other films included Portnoy's Complaint, Gable & Lombard, Silver Streak, Semi-Tough, First Monday in October, I'm Dancing As Fast I Can, It's My Turn, and Running With Scissors. She will be seen in the upcoming film Love and Other Drugs.
She also appeared on television, including Ally McBeal, Leap of Faith, The Practice, Nip/Tuck, and Dirty Sexy Money.
She is survived by her husband, the playwright David Rabe, her daughter, actress Lily Rabe, who is starring on Broadway in The Merchant of Venice, her son, Michael, and her stepson, Jason.