The scenic design will be by Alexander Dodge, with costume design by Tony Award winner Catherine Zuber, lighting design by James F. Ingalls and sound design by Jon Gottlieb. Mathias received a Tony Award nomination for Indiscretions; his other Broadway credits include Marlene, and the recent revivals of Dance of Death and The Elephant Man.

Bening, who will play Madame Ranyevskaya, received a Tony Award nomination and a Theatre World Award for her work in Coastal Disturbances. She has received Academy Award nominations for her work in The Grifters, Bugsy, American Beauty, and Being Julia. Molina, who will play Lopakhin, received Tony nominations for Art and Fiddler on the Roof, and will be seen in Kenneth Branagh's upcoming film version of As You Like It as Touchstone.