In 2015, reluctant co-workers Hal and Cassie are investigating a sad hoarder mess, sifting through the belongings of an elderly and mysterious “Jane Doe.” In 1955, in that same apartment, two strangers from different worlds, Esther and Lynley, spark an uneasy friendship, exploring their blossoming connection against all odds. Hazardous Materials digs deep into truths long buried under decades of emotional detritus. How much do we bury in a place, and within ourselves?