Featuring appearances and performances by Aloe Blacc, George Clooney, Natalie Cole, Danny DeVito, Renée Fleming, Tom Hanks, Carole King, David Letterman, Paul Shaffer, Meryl Streep, and SeriousFun Campers, the gala will raise money to support SeriousFun, helping children with serious illnesses and their families to receive a life-changing experience at a SeriousFun camp around the world.