When alcoholic patriarch Beverly Weston goes missing, his daughters Barbara, Ivy and Karen reluctantly return home to their mother Violet — cancer-stricken, drug-addled, and a bigger piece of work than ever. With in-laws, cousins, grandchildren and new beaus in tow, the entire Weston clan makes the journey to the family home, where old grievances are aired, family secrets are spilled, and cutting remarks—especially those from Violet—take deadly aim.