A Family Christmas Reunion takes place in present-day New York City. It's Christmas Eve, and members of the Rodriguez family are getting together for the holiday. The family has been divided and hasn't celebrated Christmas together in a long time. Gloria Rodriguez, the mother of Isabella, Miguel, and Jorge, has been diagnosed with leukemia and is approaching the end of her life. The only people who know are Jorge and Martha, Gloria's mother. Knowing that this might be the last Christmas they could spend together with Gloria, Jorge reaches out to the rest of the family and organizes a Christmas reunion. With this reunion comes the comedy of a Hispanic family holiday get-together as well as a confrontation with the past.