After grad school, roommates Catherine and Gwen took divergent paths in life. Catherine became a rock star academic. Gwen opted for marriage and stay-at-home motherhood. Reunited in their 40s, both face a kind of "buyer's remorse" about their life choices and wonder if it's possible to start anew. Figuring it's now or never, the pair engage in a reckless game of romantic "musical chairs" the consequences of which are both tantalizing and deeply poignant. With scorching insight and Gina Gionfriddo's distinctive wit, Rapture, Blister, Burn weaves an intimate tale of contemporary gender politics that illuminates our common struggle to achieve that ever-elusive goal called Happiness.