Magic Theatre, San Francisco's premiere home for new plays, opens its 2004-2005 Season with the world premiere of The Opposite of Sex, a wickedly funny new musical based on the cult-favorite film of the same name. With music and lyrics by Douglas J. Cohen, book by Cohen and Robert Jess Roth and directed by Roth, the show brings Broadway talent to San Francisco, including Tony Award winner Karen Ziemba and Kerry Butler. Based on the screenplay by Don Roos, the musical follows the misadventures of Dedee Truit (Butler), a 16-year-old girl, who upon the death of her stepfather, runs away from home and settles in with her gay stepbrother, Bill. She quickly grows bored in the small Midwestern town, wreaks havoc on Bill and his best friend Lucia (Ziemba), seduces his boyfriend Matt, and takes off with him. With Bill and Lucia giving chase, Dedee trash-talkes, seduces and blackmails her way from Lousiana to LA and back, leaving behind a trail of comic catastrophes.