It's Christmas Eve, 1932. Three New York guys, each preoccupied with his own particular problems and not especially fond of the season, find themselves in Good Time Charley's speakeasy on West 46th Street. As the bootleg liquor flows, the guys agree to band together and take to the road to avoid all the hubbub of the holiday. Besides, notorious racketeer Heine Schmitz is after them, and they have to get out of town. Over one long, life-changing night, they make some big decisions while inadvertently spreading good cheer around and about to one and all. Three Wise Guys is based on Damon Runyon's short stories "Dancing Dan's Christmas" and "The Three Wise Guys."