¡Oso Fabuloso & The Bear Backs! tells the story of a queer Latine bear named Oso Fabuloso (C. Julian Jiménez), who has recently been dumped by a two-timing Daddy bear. In order to overcome his depression, Oso seeks the help of his therapist Dr. Calvo (P.K. Variance), who convinces him to use his gift of song to sing the blues away. Oso agrees to go on tour with his therapist/guitarist and his two best friends/backup singers, Gummy (Vasilios Leon) and Grizz (Joseph Distl), hoping it will cure him of his romantic woes!