The Holmes siblings have just lost their mother and are cleaning out their parents' garage for the very last time. Shelby and Megan are competitive sisters with polar opposite worldviews, and their adopted African-American brother Dylan tends to have conversations with inanimate objects. They all have unresolved conflicts that get unpacked along with the mountains of boxes, crates, and bags. As the family goes through the endless pile of their parents' accumulated treasures and junk, they relive childhood milestones and touchstones, both joyous and traumatic. Things take an unexpected turn when they uncover a painting that was painted by their mother. She has left a note saying that the painting should go to her favorite child, without specifying which one of them that is. Old wounds are exposed and generously doused in salt until the afternoon comes to a climax when Shelby's husband, Ethan, makes a shocking discovery in a dusty old trunk.