In Art, a wealthy young doctor, Serge, astounds his two best friends, Marc and Ivan, when he purchases an unusual - and unusually priced - contemporary painting. When Marc confronts Serge and ridicules him for wasting his money, the three friends begin to question the nature of their relationship. As the play progresses and their wrangling escalates, it soon becomes clear that Art is less about "art" and more about the complexities of truth and loyalty in friendship.