Little Miss Muffet's Monster-Sitting Service tells the story of Molly Muffet (the great-great-great-great granddaughter of the original Little Miss Muffet) and what happens when she ends up home alone while her parents leave for a high school reunion. Molly's grandfather is called in to babysit but gets stranded by a snowstorm in Alaska. As a last resort, he calls in an old family friend, Aloisius Albrecht Alviss Spider (Al for short), the original spider from the famed nursery rhyme. Molly and Al quickly become friends and hatch a plan to start a baby-sitting service for loveable baby monsters while her parents are away.
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