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Award-winning actress Lois Smith will star in Playwrights Horizons' world premiere production of Kate Fodor's 100 Saints You Should Know, which will begin previews on August 24. The production, to be directed by Ethan McSweeny, will open officially on September 18. Additional casting will be announced shortly.

Smith will play the protective mother of a priest who is forced to leave the church under unusual circumstances. Fodor is best known as the author of Hannah & Martin. McSweeny's credits include the Broadway revival of The Best Man, Never the Sinner, and A Body of Water.

Smith is a two-time Tony Award nominee for The Grapes of Wrath and Buried Child. She received numerous major awards, including the Drama Desk and Outer Critics Circle, for the Signature production of The Trip to Bountiful, and she will return to Off-Broadway next month in Surface to Air at Symphony Space. Her film and television credits include East of Eden, Five Easy Pieces, and Truman.