LuPone takes the stage at the Wallis Annenberg Center for one night only.
The award-winning musical will receive three screenings in select US theaters.
Pam MacKinnon will direct the upcoming production.
George C. Wolfe directs the memorial concert at the Al Hirschfeld Theatre.
Tony-winning Hairspray producer Margo Lion will be the guest of honor at the annual event.
The dark comedy will be remounted with its original star after an extended run last summer.
The rock opera will offer a return engagement at Joe's Pub.
The living legend will be interviewed by Tony-winning director John Doyle.
The production partners with community organizations to give seniors access to Broadway.