The musical will make its long-awaited New York debut in time for the next Tony Awards cutoff.
The one-night-only event will be used to create the Harvey Milk Arts Fund at the Hetrick-Martin Institute.
Rimalower is also the creator of the long-running Patti Issues.
Me, My Mouth and I will make its world premiere at the Cherry Lane Theatre.
Spanger made her Broadway debut in the role in 2002.
British actress Ruth Wilson makes her Broadway debut at Manhattan Theatre Club.
Previously announced stars include Rachel Ticotin, Brad Calcaterra, and Michael Musto.
The Shakespeare-inspired musical will have its world premiere production next year.
Further casting for the musical has been announced.