Daniel Aukin directs the production, which transfers to New York after a run at Williamstown Theatre Festival.
From New York to California, the stars are coming out to reclaim their theatrical roots.
The pair replaces the previously announced Chris Pine and Lauren Ambrose at Williamstown Theatre Festival.
David Grimm's new play also features Kathleen Chalfant and Michael Esper.
John Patrick Shanley's new play also stars Peter Maloney and Dearbhla Molloy.
Award-winning Broadway veterans Nina Arianda and Kathleen Chalfant lead the cast.
Chalfant joins Tony winner Nina Arianda in the world premiere of David Grimm's new play.
Kate Whoriskey will direct this world premiere production.