Tony nominee Thomas Sadoski will costar in the world premiere of Neil LaBute's The Way We Get By.
Fred Weller and Gia Crovatin also appear in Terry Kinney's production.
The Twilight actress stars in the comedy about Hollywood at the Lucille Lortel Theatre.
The actress will be replaced by stage and screen veteran Elizabeth Reaser.
Terry Kinney directs the production, which also stars Callie Thorne, Frederick Weller, and Gia Crovatin.