The new play by Simon Stephens is directed by Trip Cullman.
Shut Up When You Talk to Me will be presented as part of MCC Theater's Playlab series.
The actress will be replaced by stage and screen veteran Elizabeth Reaser.
Terry Kinney directs the production, which also stars Callie Thorne, Frederick Weller, and Gia Crovatin.
MCC Theater will present the world premiere of LaBute's latest comedy this fall.
Sam Gold directs Penelope Skinner's new play at the Lucille Lortel Theatre.
But the writer and film star is delighted to join the cast of the American premiere of Penelope Skinner's new play.