The two-time Tony-winning actress will make her debut at the famed San Francisco venue this June.
The celebration of Leonard Bernstein will feature performances by Judy Kaye, Lauren Worsham, and more.
Full casting has been announced for the James Glossman-helmed production.
The classic musical played February 5-9.
Drama Desk Award winner Rachel York will star opposite Borle as the object of his six characters' affections.
The October 28 event will also feature Alexandra Silber and Nick Wyman.