Longtime cast member Kelso takes over the role of shoe factory owner Charlie while de Waal flies in from the national tour of Wicked to assume the role of his quirky assistant (and secret crush) Lauren.
An Evening With Tevye and Chava looked at how Sholom Aleichem's timeless characters have reflected generations of social concerns.
Tom McGowan and Mare Winningham will also be featured in the new play.
Manhattan Theatre Club's production of Fierstein's new play will begin previews April 1.
Newly announced cast members also include Malcolm Gets, Anthony Rapp, and Krysta Rodriguez.
Additional guests will include Sheldon Harnick, Chris Hayes, and Austin Pendleton.
Honorees will include Nina Tassler, Linda Lowy, and Michael J. Fox
The Tony-winning musical reached this milestone faster than any other big-budget musical in recent history.