The actress will be replaced by stage and screen veteran Elizabeth Reaser.
Terry Kinney directs the production, which also stars Callie Thorne, Frederick Weller, and Gia Crovatin.
MCC Theater will present the world premiere of LaBute's latest comedy this fall.
The Terrence McNally play also stars Bobby Steggert and Frederick Weller.
Terrence McNally's drama stars Tyne Daly.
McNally's new play at the John Golden Theatre is his 20th main stem production.
The director of Broadway's Mothers and Sons talks about the universality of Terrence McNally's latest play and hints at her next project, While I Yet Live, by Kinky Boots' Billy Porter.
Tony winner Terrence McNally's latest play deals with the incredible changes in the lives of gay Americans in the last three decades.