The production is directed by Tony winner Doug Hughes and stars Frank Langella as Sir Thomas More, with Hannah Cabell (Margaret More), Michael Esper (William Roper), Michel Gill (Duke of Norfolk), Zach Grenier (Thomas Cromwell), Dakin Matthews (Cardinal Wolsey), George Morfogen (Thomas Cranmer, Archbishop), Patrick Page (King Henry VIII), Maryann Plunkett (Alice More), Jeremy Strong (Richard Rich), Charles Borland (Jailor), Peter Bradbury (Steward), Patricia Hodges (Woman), Triney Sandoval (Thomas Chapuys) and Emily Dorsch.

The creative team includes Santo Loquasto (sets), Catherine Zuber (costumes), David Lander (lighting), and David Van Tieghem (original music/sound).