The actress will play the mild-mannered Emma, a colleague of Schmidt's (Max Greenfield) who reveals herself to be sexually adventurous.

The series, which begins its second season on September 25, stars Zooey Deschanel.

In related news, the site is also reporting that Jamie Lee Curtis and Rob Reiner will guest star as the parents of Deschanel's character, Jess.

Gugino has appeared on Broadway in After The Fall, Desire Under the Elms, and The Road to Mecca. Her film and television credits include Spy Kids, A Night at the Museum, Political Animals, Californication, and Entourage.