Connick received Tony nominations for his performance in The Pajama Game and for the score of Thou Shalt Not. He has appeared in such films as Bug, Memphis Belle, and Little Man Tate. He co-starred in the NBC series Will & Grace, the television version of South Pacific and won an Emmy Award for his special Harry Connick, Jr.: Only You in Concert.

Connick is also a top-selling, Grammy Award-winning recording artist; his most recent CD, Your Songs, was released in 2009.