The play, set in the 1980s, follows CIA operative Jim Warnock as he struggles to stop the Soviet Army's destruction of Afghanistan. The ground constantly shifts for Jim and his counterparts in the KGB and British and Pakistani secret service as the political and personal alliances between the men keeps changing.

Sher won the Tony, Drama Desk, and Outer Critics Circle Awards for directing LCT's revival of South Pacific, and was also nominated for Tony Awards for directing LCT productions of Awake & Sing! and The Light in the Piazza. He was most recently represented on Broadway by Women on the Verge of a Nervous Breakdown.

Rogers' previous plays include The Overwhelming, Madagascar, White People, Murmuring in a Dead Tongue, and Seeing the Elephant. An earlier version of Blood and Gifts was presented as part of a cycle of 11 plays about Afghanistan titled The Great Game: Afghanistan.

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