The show will feature John Douglas Thompson in the title role, Ned Eisenberg as Iago, Juliet Rylance as Desdemona, Kate Forbes as Emilia, and Lucas Hall as Cassio, along with Denis Butkus, Robert Langdon Lloyd, Elizabeth Meadows Rouse, Christian Rummel, Alexander Sovronsky, and Graham Winton.

The creative team features Peter Ksander (sets), Miranda Hoffman (costumes), Marcus Doshi (lights), Sarah Pickett (music), Matt O'Hare (sound), and B.H. Barry (fight choreography).