Ruffalo joins previously announced cast members Lauren Ambrose, Ned Eisenberg, Ben Gazzara, Jonathan Hadary, Peter Kybart, Pablo Schreiber, Richard Topol, and Zoe Wanamaker. The production's design team includes Michael Yeargan (sets), Catherine Zuber (costumes), and Christopher Akerlind (lighting).
Awake and Sing! will mark Ruffalo's Broadway debut. He received a Theater World Award for his Off-Broadway performance in This Is Our Youth. Among his film credits are You Can Count on Me, In the Cut, and the recently released Rumor Has It.