The Laramie Project: 10 Years Later focuses on the long-term effect of the murder of Matthew Shepard on the town of Laramie. It explores how the town has changed and how the murder continues to reverberate in the community. The play also includes new interviews with Matthew's mother Judy Shepard and Matthew's murderer Aaron McKinney, who's serving dual life sentences, as well as follow-up interviews with many of the individuals from the original piece.

Immediately after the global reading, the Guthrie will participate in a special talkback featuring a panel at Lincoln Center's Alice Tully Hall that will include creators, cast members, and other key individuals involved in The Laramie Project: 10 Years Later. The talkback is made possible via a special satellite hookup, with participating theaters from around the country able to submit questions via Twitter.