After his wife leaves him, beloved high school biology teacher Andrew Goodspeed suffers a mild heart attack. In an effort to make sense of his disillusionment, Andrew devises a new course for his students: a study of the science of love. Sharon, Andrew's best student, is convinced that she is incapable of love. She manipulates the experiment, her teachers, and her peers to prove this theory. But she and Andrew begin to wonder: can true love be proven by observable physiological data? Against his better judgment, Andrew allows Sharon to guide the experiment down a more intimate track, putting his job and his reputation in jeopardy.
Word of Andrew's exploits spreads to an evangelical congressman with a personal interest in the story. Accusations of impropriety and misconduct fly, as the lines between student and teacher, science and spirituality blur. According to the congressman, love is the province of religion, not science. And by bringing love into the classroom has Andrew opened the door to God as well?
Wonderlust explores the mysteries of love, and our expectations of it in contemporary American culture. Should it be dissected and studied? Should it be chalked up to faith? Or is it best left a thing of wonder?