Set in modern day Manhattan, Prelude to a Kiss tells the story of Peter and Rita, who meet at a friend's party. He has a boring job in medical publishing, and she's a bartender with insomnia. Neither of them is remarkably ambitious, but they find common ground on a number of subjects (Freud's case histories, Rita's brief tenure as a Socialist, etc.). They hit it off right away, and begin a whirlwind romance that culminates in wedding bells within only a few months. After a mysterious elderly man appears and kisses the bride at the wedding, the two lovers are sent on a magical journey that they will never forget. As they struggle to come to terms with their relationship and Rita's nagging doubts, their love is put to the test by unknown forces.