Brian DeGryse is one of the university's most desirable men. He has a girlfriend named Annie; he's sleeping with one of his teachers, and he's about to start an affair with an older woman named Caitlin Carter, who has secrets of her own.
Brian's roommate, Hampton, has just come out of the closet, much to the dismay of his best friend, Rocker, an All-American football player, who has just started to date the university's homecoming queen, Marilyn Cooper.
Hampton falls head over heels for a male hustler named Billy, as Brian hallucinates on mushrooms and carries on conversations with Greg, a giant Kafka type bug.
Will Brian settle down with Annie, or will he get tangled up in even more scandalous affairs? Will Hampton hook up with Billy, and will Rocker accept Hampton for who he really is? And what about Greg? Will Greg's parents accept him for the bug he's become?