Ouisa Kittredge read somewhere that "everybody on this planet is separated by only six other people." When Paul, a young victim of a knife attack, seeks assistance at her family's upper-class New York home, she discovers how true that statement really is.

Claiming to be Sidney's Poitier's son, Paul connects to Ouisa and her husband Flan in a way not even their own children have. But Paul may not be all he says he is, and his aggressive, far-reaching search for meaningful human contact creates a web of confusion and pain that - as Ouisa discovers - didn't start, nor end, within her family's walls.

A comic-tragedy loosely based on a true story, John Guare's Six Degrees of Separation, like a revolving Kandinsky, paints multiple sides on what drives and motivates us in the glare of money, greed, fame, lust and, finally, each other.