Red Noses follows the exploits of one inspired (and possibly mad) holy man and his motley crew of followers as they seek to relieve the suffering of the masses through laughter. Humankind has reverted to the basest means of survival, and our once ordered world has been turned upside-down. Some believe the plague is God's wrath which must be appeased through suffering. Others are determined to exploit the crisis to their own benefit. Still others have thrown up their hands and decided to ride it out in wanton debauchery. In the midst of this chaos, Father Flote and his "Floties" somehow manage to make the people smile again. In the midst of disaster, Flote hopes.